Role of PKG II in osteoblast mechanotransduction
نویسندگان
چکیده
Background Mechanical stress is a primary determinant of bone growth and remodeling: weight bearing and locomotion stimulate interstitial fluid flow through the bone canalicular system, and the resultant shear stress is a major mechanism whereby mechanical forces stimulate bone growth [1]. In response to fluid shear stress and other types of mechanical stimulation, osteoblasts produce large amounts of NO, and genetic and pharmacologic studies indicate an important role of NO in osteoblast biology, but little is known about signaling downstream of NO in osteoblasts [1,2].
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